{"id":145,"date":"2025-01-13T09:47:43","date_gmt":"2025-01-13T09:47:43","guid":{"rendered":"https:\/\/www.biomai.sk\/?p=145"},"modified":"2025-05-15T20:37:43","modified_gmt":"2025-05-15T20:37:43","slug":"posuvame-hranice-genetickeho-vyskumu","status":"publish","type":"post","link":"https:\/\/www.biomai.sk\/en\/posuvame-hranice-genetickeho-vyskumu\/","title":{"rendered":"The Secret of Embryos: New Possibilities for Predicting IVF Success"},"content":{"rendered":"
V na\u0161ej ned\u00e1vnej publik\u00e1cii (Toporcerov\u00e1 a kol., 2025) sme priniesli nov\u00fd poh\u013ead na to, ako lep\u0161ie predpoveda\u0165 kvalitu embry\u00ed a \u00faspe\u0161nos\u0165 umel\u00e9ho oplodnenia (IVF). V najnov\u0161ej \u0161t\u00fadii publikovanej v prest\u00ed\u017enom \u010dasopise Reproductive BioMedicine Online sme sa zamerali na tzv. embryon\u00e1lny sekret\u00f3m \u2013 s\u00fabor l\u00e1tok, ktor\u00e9 embryo uvo\u013e\u0148uje do kultiva\u010dn\u00e9ho m\u00e9dia po\u010das svojho v\u00fdvoja v laborat\u00f3rnych podmienkach.<\/p>\n\n\n\n
During its development in the incubator, the embryo \u201ccommunicates\u201d with its environment by releasing various molecules \u2013 from proteins and metabolites to small non-coding RNAs. Together, these molecules form the so-called secretome, which several researchers have analyzed to determine whether it is possible to estimate embryo quality and its chances for successful implantation.<\/p>\n\n\n\n
In IVF procedures, selecting the right embryo is crucial for a successful pregnancy. Until now, selection has been primarily based on the visual assessment of the embryo, which can be insufficient. This study shows that biochemical analysis of the culture medium can be a valuable complement in deciding which embryo has the highest chance for successful development.<\/p>\n\n\n\n
Researchers identified several molecules in the culture medium \u2013 including small non-coding RNAs and metabolites \u2013 that were associated with embryo quality and IVF success. These findings open the door to non-invasive biomarkers that could, in the future, improve the success of assisted reproduction and minimize the number of unsuccessful attempts.<\/p>\n\n\n\n